Indications
Zoana is indicated for the
treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia and
Entamoeba histolytica.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Nitazoxanide is a synthetic
antiprotozoal agent for oral administration. The antiprotozoal activity of
Nitazoxanide is believed to be interference with the Pyruvate Ferredoxin Oxido
Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is
essential for anaerobic energy metabolism of the protozoa. Nitazoxanide and its
metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites
and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage & Administration
Age 1-3 years: 1 tea-spoonfull or
5 ml suspension every 12 hours for 3 days.
Age 4-11 years: 2 tea-spoonfulls
or 10 ml suspension every 12 hours for 3 days.
Age 12 years or above: 5
tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days.
It is recommended to be
administered with food.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
It is highly bound to plasma
protein. Therefore, caution should be exercised when administering Zoana
concurrently with other highly plasma protein-bound drugs with narrow
therapeutic index.
Contraindications
It is contraindicated in patients
with known hypersensitivity to Nitazoxanide or any components of the
preparation.
Side Effects
The most frequent side effects,
reported by Zoana are abdominal pain, vomiting and headache. These side effects
are typically mild and transient in nature. Very rare side effects include-
nausea, anorexia, flatulence, increased appetite, enlarged salivary glands,
increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness,
discolored urine etc.
Pregnancy & Lactation
US FDA pregnancy category of
Nitazoxanide is B. There are, however, no adequate and well-controlled studies
in pregnant women. Because animal reproduction studies are not always
predictive of human response, this drug should be used during pregnancy only if
clearly needed. Nitazoxanide have been shown to be excreted in human milk. So, caution
should be exercised when Nitazoxanide is administered during lactation.
Precautions & Warnings
Zoana must be administered with
caution to patients with hepatic & biliary disease and to patients with
renal disease.
Therapeutic Class
Anti-diarrhoeal Antiprotozoal
Storage Conditions
Keep in a dry place away from
light and heat. Keep out of the reach of children.
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