UNSAFE
- It is unsafe to consume alcohol with Xpa 500.
SAFE IF PRESCRIBED
- Xpa 500 is safe to use during pregnancy. Most studies have
shown low or no risk to the developing baby.
SAFE IF PRESCRIBED
- Xpa 500 is safe to use during breastfeeding. Human studies
suggest that the drug does not pass into the breastmilk in a significant amount
and is not harmful to the baby.
SAFE
- Xpa 500 does not usually affect your ability to drive.
CAUTION
- Xpa 500 should be used with caution in patients with kidney
disease. Dose adjustment of Xpa 500 may be needed. Please consult your doctor.
However, Xpa 500 contains paracetamol which is considered the safest painkiller
for kidney disease patients.
CAUTION
- Xpa 500 should be used with caution in patients with liver
disease. Dose adjustment of Xpa 500 may be needed. Please consult your doctor.
However, the use of Xpa 500 is not recommended in patients with severe liver
disease and active liver disease.
- Medicine Overview of Xpa 500mg Tablet
Introduction
- Xpa 500 500mg is a medicine used to relieve pain and to
reduce fever. It is used to treat many conditions such as headache, body ache,
toothache and common cold.Xpa 500 may be prescr500mg ibed alone or in
combination with another medicine. You should take it regularly as advised by
your doctor. It is usually best taken with food otherwise it may upset your
stomach. Do not take more or use it for longer than recommended. Side effects
are rare if this medicine is used correctly but this medicine may cause stomach
pain, nausea, and vomiting in some people. Consult your doctor if any of these
side effects bother you or do not go away.This medicine is widely prescribed
and considered safe but is not suitable for everybody. Before taking it, let
your doctor know if you have liver or kidney problems or are using
blood-thinning medicines. It may affect the dose or suitability of this
medicine. Let your doctor know about all the other medicines you are taking
because they may affect, or be affected by, this medicine.
Uses of Xpa 500
Side effects of Xpa 500
- Common
- No common side effects seen
How to use Xpa 500
- Take Xpa 500 500mg medicine in the dose and duration as
advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Xpa 500 500mg is to be taken with food.
How Xpa 500 works
- Xpa 500 500mg is an analgesic (pain reliever) and
anti-pyretic (fever reducer). It works by blocking the release of certain
chemical messengers that cause pain and fever. Xpa 500 is an analgesic (pain
reliever) and anti-pyretic (fever reducer). It works by blocking the release of
certain chemical messengers that cause pain and fever.
What if you forget to take Xpa 500?
If you miss a dose of Xpa 500 500mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not doubleIf you miss a dose of Xpa 500 500mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
Xpa 500 should be taken with food or milk to prevent upset
stomach.
Take it as per the dose and duration prescribed by your
doctor. Long term use may lead to serious complications such as stomach
bleeding and kidney problems.
Do not take indigestion remedies (antacids) within two hours
of taking Xpa 500.
Avoid consuming alcohol while taking this medicine as it can
increase your risk of stomach problems.
Inform your doctor if you have liver disease as your dose
may need to be adjusted.
Your doctor may regularly monitor your kidney function,
liver function and levels of blood components if you are taking this medicine
for long-term treatment.
Brief Description
Indication
- Fever, Mild to moderate pain, osteoarthritis, rheumatoid
arthritis, chronic low back pain, Renal stone pain, neuropathic pain,
toothache, migraine, postoperative mild to moderate pain.
Administration
- May be taken with or without food.
Adult Dose
- Oral Mild to moderate pain and fever Tablet Adult: 1 - 2
tablets every 4 to 6 hours up to a maximum of 4 g (8 tablets) daily Extended
Release (XR) Tablet Adults: 2 tablets, swallowed whole, every 6 to 8 hours
(maximum of 6 tablets in any 24 hours). Syrup/Suspension: Adults: 4-8 Measuring
spoonful 3-4 times daily; Rectal Suppository Adults: 500 mg-1 g every 4-6 hours
to a maximum of 4 g daily.
Child Dose
- Oral Mild to moderate pain and fever Tablet Children (6 - 12
years) : 1/2 to 1 tablet 3 to 4 times daily Extended Release (XR) Tablet
Children over 12 years: 2 tablets, swallowed whole, every 6 to 8 hours (maximum
of 6 tablets in any 24 hours). Syrup Mild to moderate pain and fever Children:
3 months - <1 year : 60 - 120 mg (1/2 - 1 measuring spoonful), 1 - 5 years :
1 - 2 measuring spoonful 6 - 12 years : 2 - 4 measuring spoonful Children: 2
months: 60 mg (1/2 measuring spoonful) for post immunization pyrexia;
Paediatric Drops Mild to moderate pain and fever Children Up to 3 months: 0.5
ml (40 mg) 4 to 11 months: 1.0 ml (80 mg) 1 to <2 years: 1.5 ml (120 mg) 2
to 3 years: 2 ml (160mg) 4 to 5 years: 3 ml (240 mg) Dose can be repeated,
every 4 hours. Rectal Mild to moderate pain and fever Suppository Children: 3
months-<1 year: 60-125 mg 1-<5 years: 125-250 mg 5-12 years: 250-500 mg
These doses may be repeated every 4-6 hours as necessary (maximum 4 doses in 24
hours). Children over 12 years: 500 mg-1 g every 4-6 hours to a maximum of 4 g
daily. Post-immunisation pyrexia Child: 2-3 mth 60 mg. If necessary, a 2nd dose
may be given after 4-6 hr.
Contraindication
Hypersensitivity.
Mode of Action
- Paracetamol exhibits analgesic action by peripheral blockage
of pain impulse generation. It produces antipyresis by inhibiting the
hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is
related to inhibition of prostaglandin synthesis in the CNS
Precaution
- Patient w/ chronic alcoholism, known G6PD deficiency, severe
hypovolaemia, chronic malnutrition. Renal and hepatic impairment. Pregnancy and
lactation. Monitoring Parameters Monitor serum paracetamol levels esp when
acute overdosage is suspected and w/ long-term use.
Side Effect
- Thrombocytopenia, leucopenia, pancytopenia, neutropenia,
agranulocytosis, pain and burning sensation at inj site. Rarely, hypotension
and tachycardia. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal
necrolysis, acute generalised exanthematous pustulosis, acute renal tubular
necrosis and hepatotoxicity.
Interaction
- May reduce serum levels w/ anticonvulsants (e.g. phenytoin,
barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin
and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and
domperidone. May increase serum levels w/ probenecid. May increase serum levels
of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin.
May cause severe hypothermia w/ phenothiazine.