Indications
Zoana is indicated for the treatment of diarrhea caused by
Cryptosporidium parvum, Giardia lamblia and Entamoeba histolytica.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Nitazoxanide is a synthetic antiprotozoal agent for oral
administration. The antiprotozoal activity of Nitazoxanide is believed to be
interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR)
enzyme-dependant electron transfer reaction. This reaction is essential for
anaerobic energy metabolism of the protozoa. Nitazoxanide and its metabolites,
tizoxanid are active in vitro in inhibiting the growth of sporozoites and
oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage & Administration
Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12
hours for 3 days.
Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every
12 hours for 3 days.
Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension
or 1 tablet every 12 hours for 3 days.
It is recommended to be administered with food.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
It is highly bound to plasma protein. Therefore, caution
should be exercised when administering Zoana concurrently with other highly
plasma protein-bound drugs with narrow therapeutic index.
Contraindications
It is contraindicated in patients with known
hypersensitivity to Nitazoxanide or any components of the preparation.
Side Effects
The most frequent side effects, reported by Zoana are
abdominal pain, vomiting and headache. These side effects are typically mild
and transient in nature. Very rare side effects include- nausea, anorexia,
flatulence, increased appetite, enlarged salivary glands, increased creatinine
& SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine
etc.
Pregnancy & Lactation
US FDA pregnancy category of Nitazoxanide is B. There are,
however, no adequate and well-controlled studies in pregnant women. Because
animal reproduction studies are not always predictive of human response, this
drug should be used during pregnancy only if clearly needed. Nitazoxanide have
been shown to be excreted in human milk. So, caution should be exercised when
Nitazoxanide is administered during lactation.
Precautions & Warnings
Zoana must be administered with caution to patients with
hepatic & biliary disease and to patients with renal disease.
Therapeutic Class
Anti-diarrhoeal Antiprotozoal
Storage Conditions
Keep in a dry place away from light and heat. Keep out of
the reach of children.
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