Indications
Trimet is indicated in adults as
add-on therapy for the symptomatic treatment of patients with stable angina
pectoris who are inadequately controlled by or intolerant to first-line
antianginal therapies.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Trimetazidine Dihydrochloride is
the first 3- keto acyl CoA thiolase inhibitor (KAT), a metabolic anti-ischemic
agent with proven benefits for all coronary patients. Trimetazidine
Dihydrochloride inhibits fatty acid pathway by inhibiting 3-keto acyl CoA
thiolase enzyme and transfers oxygen to glucose pathway. Since glucose pathway
is more efficient in producing energy, the same oxygen produces more energy and
makes the heart more active. Moreover, the aerobic oxidation of glucose stops
production of lactic acid, which prevents angina pectoris.
Dosage & Administration
The recommended dose of
Trimetazidine is 35 mg twice daily or 20 mg tablet thrice daily during meals.
The benefit of the treatment should be assessed after three months and
Trimetazidine should be discontinued if there is no treatment response.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
No drug interaction so far has
been reported. In particular, no interaction has been reported with
beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents or
digitalis preparation.
Contraindications
Trimetazidine is contraindicated
in patients who have hypersensitivity to the active substance or to any of the
excipients. It is also is contraindicated in patients with Parkinson’s disease,
parkinsonian symptoms, tremors, restless legs movement disorders, severe renal
impairment.
Side Effects
Trimet is safe and well
tolerated. The Common side effects associated with Trimet are dizziness,
headache, abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, rash,
pruritus, urticaria and asthenia
Pregnancy & Lactation
There is no data on the use of
Trimetazidine in pregnant women. Animal studies do not indicate direct or
indirect harmful effects with respect to reproductive toxicity. As a
precautionary measure, it is preferable to avoid the use of Trimetazidine
during pregnancy. It is unknown whether Trimetazidine is excreted in human
milk. A risk to the newborns/infants cannot be excluded. Trimetazidine should
not be used during breast-feeding.
Precautions & Warnings
Trimet is not a curative
treatment for angina attacks, nor an initial treatment for unstable angina
pectoris. It is also not a treatment for myocardial infarction.
Therapeutic Class
Other Anti-anginal & Anti-ischaemic
drugs
Storage Conditions
Keep in a dry place away from
light and heat. Keep out of the reach of children.
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