Introduction
Tofix 200 is a pain relieving medicine. It is used for
treatment of pain associated with acute attacks of migraine in adults. It may
also be used to relief pain associated with joints and muscles. Tofix 200 can
be taken with food, preferably with a glass of water. The dose and duration
will depend on what you are taking it for and how well it helps your symptoms.
You should keep taking the medicine even if you feel better until the doctor
says it is alright to stop using it. The most common side effects of this medicine
include mild indigestion, diarrhea, nausea, vomiting, stomach pain, rash,
headache, and dizziness. If any of these side effects persist or get worse, you
should let your doctor know. Your doctor may be able to suggest ways of
preventing or reducing the symptoms. Before using it, you should let your
doctor know if you have a history of stomach ulcers, heart diseases, high blood
pressure, and liver or kidney disease. Let your doctor also know about all the
other medicines you are taking because they may affect, or be affected by, this
medicine. Pregnant and breastfeeding mothers should consult their doctors
before using the medicine.
Uses of Tofix 200
Pain relief
Side effects of Tofix 200
Common
Vomiting
Nausea
Indigestion
Diarrhea
Heartburn
Loss of appetite
How to use Tofix 200
Take this medicine in the dose and duration as advised by
your doctor. Do not chew, crush or break it. Tofix 200 is to be taken with
food.
How Tofix 200 works
Tofix 200 is a non-steroidal anti-inflammatory drug (NSAID).
It works by blocking the release of certain chemical messengers that cause
fever, pain and inflammation (redness and swelling).
Quick Tips
It should be taken with food or milk to avoid getting an
upset stomach.
It can cause serious complications like stomach bleeding and
kidney problems if taken for a long time.
Tofix 200 can raise your risk of blood clots, heart attack,
or a stroke.
Inform your doctor if you are pregnant or planning to
conceive or breastfeeding.
Inform your doctor if you have ever been diagnosed with
kidney or liver problems.
Brief Description
Indication
Mild to moderate pain, Acute migraine attacks
Administration
Should be taken with food. Take w/ or immediately after
meals.
Adult Dose
Oral Acute migraine attacks Adult: 200 mg when 1st symptoms
appear, may be repeated after 1-2 hr, if necessary. Mild to moderate pain
Adult: 100-200 mg tid. Hepatic impairment: Severe: Avoid.
Renal Dose
Renal impairment: Severe: Avoid.
Contraindication
Hypersensitivity to aspirin or other NSAID. Active or
history of GI bleeding or ulceration, severe heart failure, history of GI
bleeding or perforation related to previous NSAID therapy. Severe renal and
hepatic impairment. Pregnancy (3rd trimester).
Mode of Action
Tolfenamic acid, an anthranilic acid derivative, is an
NSAID. It has anti-inflammatory, analgesic and antipyretic effects.
Precaution
Patient w/ or w/ history of bronchial asthma, uncontrolled
HTN, CHF, established ischaemic heart disease, peripheral arterial disease,
cerebrovascular disease, coagulation defects, SLE, connective tissue disorders,
history of GI disease (e.g. Crohn's disease, ulcerative colitis). Hepatic and
renal impairment. Pregnancy and lactation. Patient Counselling This drug may
cause dizziness, drowsiness, fatigue and visual disturbances, if affected, do
not drive or operate machinery. Monitoring Parameters Monitor renal function.
Side Effect
Dysuria esp in males; tremor, euphoria, fatigue, pulmonary
infiltration, nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia,
abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of
Crohn's disease and colitis, gastritis, pancreatitis; oedema, HTN, cardiac
failure; nephritis, hepatitis, jaundice, abnormal liver function; visual
disturbances, optic neuritis, headache, paraesthesia, depression, confusion,
hallucinations, tinnitus, vertigo, tremor, dizziness, malaise, drowsiness;
thrombocytopenia, neutropenia, agranulocytosis, anaemia. Potentially Fatal:
Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis;
GI bleeding, ulceration or perforation.
Interaction
Increased rate of absorption of tolfenamic acid with
metoclopramide and magnesium hydroxide. Decreased rate of absorption of
tolfenamic acid with aluminium hydroxide. Increased risk of bleeding with
anticoagulants and other NSAIDs. Decreased antihypertensive response to loop
diuretics, ?-blockers and ACE inhibitors. Coadmin increased plasma
concentrations of lithium, methotrexate and cardiac glycosides. Increased risk
of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics.
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