Indication
Relief of cough with associated
congestive symptoms
Administration
May be taken with or without
food.
Adult Dose
Adults: Syrup 2 tsf 4 times a
day. For night time cough relief 2 tsf at bedtime followed by 2 tsf every 6
hours. Hepatic dysfunction Subjects with moderate to severe hepatic dysfunction
should exercise caution when using this product
Child Dose
Children>12 years and over:
Syrup 2 tsf 4 times a day. For night time cough relief 2 tsf at bedtime
followed by 2 tsf every 6 hours. Children<12 years: Safety & Efficacy
not established
Renal Dose
Subjects with moderate to severe
renal dysfunction should exercise caution when using this product
Contraindication
Known hypersensitivity to the
product or any of its constituents. Not to be used in children under the age of
12 years.
Mode of Action
Diphenhydramine is a potent
antihistamine and antitussive with anticholinergic and sedative properties.
Recent experiments have shown that the antitussive action is discrete from
H1-receptor blockade and is located in the brain stem. Guaifenesin is reported
to reduce the viscosity of tenacious sputum and is used as an expectorant.
Levomenthol has mild local anaesthetic and decongestant properties.
Precaution
This product should be not used
for persistent or chronic cough, such as occurs with asthma, or where cough is
accompanied by excessive secretion. May impair ability to drive or operate
machinery. Should be used with caution in patients with narrow-angle glaucoma
or symptomatic prostatic hypertrophy. Avoid alcohol.
Side Effect
Diphenhydramine may cause
drowsiness, dizziness, gastrointestinal disturbance; dry mouth nose and throat;
difficulty in urination or blurred vision. Less frequently it may cause
palpitations, tremor, convulsions or paraesthesia. Hypersensitivity reactions
have been reported, in particular, skin rashes, erythema, urticaria and
angiodema. Gastro-intestinal discomfort, nausea and vomiting have occasionally
been reported with guaifenesin particularly in large doses. Adverse reactions
to levomenthol at the low concentration present are not anticipated.
Interaction
This product contains
diphenhydramine and therefore may potentiate the effects of alcohol, codeine,
antihistamines and other CNS depressants. As diphenhydramine possesses some
anticholinergic activity, the effects of anticholinergics (e.g. some
psychotropic drugs and atropine) may be potentiated by this product. This may
result in tachycardia, dry mouth, gastrointestinal disturbances (e.g. colic),
urinary retention and headache.
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