Indications
Radifylin is used to treat in following indications:
Bronchial asthma,
Bronchospasm,
Chronic obstructive pulmonary disease (COPD),
Pulmonary disease with spastic bronchial component.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Doxophylline is a novel bronchodilator. It structurally
differs from Theophylline due to the presence of a dioxolane group in position
7. Doxophylline selectively inhibits phosphodiesterase 4 thereby relaxes
bronchial smooth muscle. However, differently from Theophylline, Doxophylline
appears to have decreased affinities toward adenosine A1 and A2 receptors,
which may account for the better safety profile of the drug. Doxophylline is
reported to inhibit platelet activating factor (PAF) and generation of
leukotriene production.
Dosage & Administration
Elderly: 200 mg tablet two or three times daily.
Adults: 400 mg tablet two or three times daily or as
prescribed by the physician.
Children:
>12 years of age: 10 ml syrup or 200 mg tablet two or
three times daily.
6-12 years of age: 6-9 mg/kg body weight two times daily,
i.e. if body weight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by
the physician.
If required daily dose of Doxophylline is 400 mg then
Doxophylline SR tablet to be taken once daily or as prescribed by the physician
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Radifylin should not be administered with other xanthine
preparations. It is recommended to limit consumption of beverages and food
containing caffeine. Caution should be exercised in administering Radifylin
together with ephedrine or other sympathomimetic drugs. The concurrent
administration of many drugs such as erythromycin, TAO, lincomycin,
clindamycin, allopurinol, cimetidine, influenza vaccine and propanolol may
reduce the hepatic clearance of xanthine derivatives with an increase in the plasmatic
levels of the drug. Phenytoin, other anticonvulsants and cigarette smoking may
increase the clearance of xanthine derivatives with a reduction of plasmatic
half-life. In these cases, it may be necessary to increase the dosage of the
drug.
Contraindications
Doxophylline is contraindicated in individuals with known
hypersensitivity to the drug or other xanthine derivatives. It is also
contraindicated in patients with acute myocardial infarction, hypotension and
during lactation.
Side Effects
Patients treated with xanthine derivatives may suffer
nausea, vomiting, epigastric pain, headache, irritability, insomnia,
tachycardia, extrasystoles, tachypnea and in rare cases hyperglycemia or
albuminuria. In case of overdose severe cardiac arrhythmias and tonic-clonic
seizure may occur. These effects may represent the first signs of intoxication.
The appearance of side effects may require discontinuation of the treatment
which, if necessary, at the physician's discretion, may be resumed at lower
doses after all signs and symptoms of toxicity have subsided.
Pregnancy & Lactation
Pregnancy and Lactation: Animal tests have shown that the
active ingredient of Doxophylline does not interfere with pre and postnatal
growth. However, as there is not sufficient clinical evidence about the effects
of the drug during pregnancy, use of the drug during pregnancy should be
evaluated carefully case by case on the basis of the risk-benefit ratio. The
drug is contraindicated during lactation.
Effects on ability to drive and use machines: The product
does not affect the patient's alertness and therefore does not interfere with
his/her ability to drive and use machines.
Precautions & Warnings
Numerous factors may reduce the hepatic clearance of
xanthine derivatives with increased plasma levels of the drug. These factors
include age, congestive cardiac decompensation, chronic obstructive pulmonary
disease, severe liver disease, concomitant infections, and the concurrent
administration of several drugs such as: erythromycin, TAO, lincomycin,
clindamycin, allopurinol, cimetidine, influenza vaccine and propanolol. In
these cases, it may be necessary to reduce the dosage of the drug. In case of
factors that may influence the clearance of xanthine derivatives, monitoring of
the concentration of the blood levels of the drug is recommended for the
control of the therapeutic range.
Caution should be taken in administering the product to
patients with cardiac disease, hypertension, in the elderly, in patients with
severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart
failure, liver disease, peptic ulcer and in those with renal impairment. In
particular, it is to be used with caution in patients with congestive heart
failure, since the clearance of the drug is considerably slower in these
patients in which high blood levels may persist for long periods even after
discontinuation of the treatment. There is no risk of addiction or any other
form of dependence.
Overdose Effects
In case of overdose severe cardiac arrhythmias and
tonic-clonic seizure may occur. These effects may represent the first signs of
intoxication. The appearance of side effects may require discontinuation of the
treatment which, if necessary, at the physician’s discretion, may be resumed at
lower doses after all signs and symptoms of toxicity have subsided. As there is
no specific antidote, in case of overdose a symptomatic treatment of
cardiovascular collapse should be instituted.
Therapeutic Class
Bronchodilator, Methyl xanthine derivatives
Storage Conditions
Keep in a dry place away from light and heat. Keep out of
the reach of children. Radifylin should be used only on prescription of
specialist physician.
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