Treatment or prevention of,
Vitamin C Deficiency, Scurvy, Infection, Trauma, Burns, Cold exposure,
Following Surgery, common cold, Fever, scurvy, Stress, Cancer,
Methaemoglobinaemia and Children receiving unfortified formulas. Also indicated
in, Hematuria, Dental Caries, Gum Diseases, Pyorrhea, Acne, Infertility,
Atherosclerosis, Fractures, Leg ulcers, Hay fever, Vascular thrombosis
prevention, Levodopa toxicity, Arsenic toxicity.
Administration
May be taken with or without
food. IV Preparation Dilute with large volume of compatible fluid to minimize
adverse reactions Compatible w/ most common diluents (dextrose solns, NS, LR,
Ringer's, ½NS, dextrose-saline, dextrose-LR etc) IV Administration Avoid rapid
infusion
Adult Dose
Oral Scurvy Adult: Prevention:
25-75 mg daily. 4 tablets 2 to 3 times daily. Treatment: >250 mg daily,
given in divided doses. May also be given via IM/IV/SC admin. 250-500mg IV
qDay/BID for at least 2 weeks. Thalassaemia Adult: 100-200 mg daily, to be given
with desferrioxamine. Common cold: 1 gm or more daily in divided doses, i.e. 4
tablets daily. In wound healing: 2-4 tablets 2 to 3 times daily In other
conditions: 1-2 tablets daily For the reduction of risk of stroke in the
elderly: 1-2 tablets daily. 1 effervescent tablet daily with a meal or as
directed by physician. Dissolve one tablet in half glass (100 ml) of water and
drink instantly.
Child Dose
Children: Child: 1 mth-4 yr:
125-250 mg daily; 4-12 yr: 250-500 mg daily; 12-18 yr: 500 mg-1 g daily. Doses
to be given in 1-2 divided doses. Thalassaemia Child: 100-200 mg daily, to be
given with desferrioxamine. Metabolic disorders Child: Neonate: 50-200 mg
daily, adjust if needed; 1 mth-18 yr: 200-400 mg daily in 1-2 divided doses, up
to 1 g daily may be needed.
Mode of Action
Vitamin C: Necessary for collagen
formation and tissue repair; plays a role in oxidation/reduction reactions as
well as other metabolic pathways including synthesis of catecholamines,
carnitine, and steroids; also plays a role in conversion of folic acid to
folinic acid.
Precaution
Should be given with caution to
patient with hyperoxaluria.