Indications

• Grincal D is indicated in following cases-
• Treatment of osteoporosis, rickets, osteomalacia, tetany and hypoparathyroidism
• In pregnancy and lactation due to increased demand
• In kidney disease and pancreatitis
• During therapy with anti seizure medications
• The prevention and treatment of Calcium and Vitamin D3 deficiency

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'*

Composition

• Each film coated tablet contains-
• Calcium Carbonate (Algae Source) BP 1250 mg equivalent to elemental Calcium 500 mg.
• Vitamin D3 200 IU as Cholecalciferol USP.

Pharmacology

• Calcium (Algae Source) is an essential element and plays vital role in the body. It makes body's framework stronger by building bones. Clinical evidence suggests that calcium is useful for prevention and treatment of osteoporosis and associated fractures. Vitamin D3 is also essential for healthy bones as it aids in calcium absorption from the Gl tract. In addition to this it stimulates bone formation. Controlled clinical studies show that Calcium and Vitamin D3 have synergistic effects on bone growth as well as in osteoporosis and fracture prevention.

Dosage & Administration

• Usual adult dose: 1 tablet in the morning and 1 tablet at night. Tablet should be taken orally.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'*

Interaction

• With medicine:
• Calcium salts reduce absorption of bisphosphonates, ciprofloxacin, fluorides, iron, levothyroxine, tetracycline and zinc
• Absorption of calcium salts is reduced by corticosteroids
• Increased risk of hypercalcemia when Calcium and Vitamin D3 given with thiazides and related diuretics
• With food and others: No clinically significant food drug interaction have been reported.

Contraindications

• Hypocalcemia and hypercalciuria

Metastatic calcification

• Hypersensitivity to any of the components of Calcium and Vitamin D3 preparation

Side Effects

• Common side effects of Calcium and Vitamin D3 may include an irregular heartbeat, nausea, dry mouth, weakness, headache, a metallic taste in mouth, muscle or bone pain and drowsiness. Rare side effects are high amount of Calcium in blood, constipation, diarrhoea, loss of appetite.

Pregnancy & Lactation

• During pregnancy & lactation: Calcium and Vitamin D3 should be used considering the risk-benefit ratio.

Precautions & Warnings

• Caution should be taken in patients with renal impairment, sarcoidosis, hypercalcemia and hypercalciuria.

Use in Special Populations

• Not recommended for children under 12 years.

Overdose Effects

• At high doses it may result in nausea, vomiting, dizziness, anorexia, abdominal cramps, headache, constipation etc. Treatment includes cessation of therapy & adequate rehydration.

Therapeutic Class

• Specific mineral & vitamin combined preparations

Storage Conditions

• Store below 30°C and away from light & moisture. Keep out of the reach of children.