Indications
Covikil is indicated in-
Acute and chronic rheumatoid
arthritis
Systemic Lupus Erythematosus
(SLE)
Malaria
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Hydroxychloroquine Sulphate
synthetically produced version of quinine. It acts as an immunosuppressant by
inhibiting production of rheumatoid and acute phase reactants. It also
accumulates in white blood cells, stabilizing lysosomal membranes and
inhibiting the activity of many enzymes, including collagenase and the
proteases that cause cartilage breakdown. It also acts by disrupting cell walls
of infected red blood cells and kills the developing parasites.
Dosage & Administration
Hydroxychloroquine Sulphate
tablets are for oral administration and are taken with food to avoid stomach
upset.
Acute and chronic rheumatoid
arthritis: 400 to 600 mg daily. When good response is obtained (usually 4 to 8
weeks), dose can be reduced to 50%.
Systemic Lupus Erythematosus
(SLE): 400 mg once or twice daily for several weeks or months depending on
response of the patients. Maintenance dose is 200 to 400 mg daily.
Malaria: In adults, an initial
dose of 800 mg followed by 400 mg in 6-8 hours and 400 mg on each of two
consecutive days. For children a total dose representing 25 mg/kg is
administered in 3 days as follows.
First dose: 10 mg base/kg (but
not exceeding a single dose of 620 mg base).
Second dose: 5 mg base/kg (but
not exceeding a single dose of 310 mg base) 6 hours after first dose.
Third dose: 5 mg base/kg 18 hours
after second dose.
Fourth dose: 5 mg base/kg 24
hours after third dose.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Side Effects
Generally Covikil is well
tolerated. However, few side effects like nausea, vomiting, stomach upset, loss
of appetite, diarrhea, tiredness, weakness or headache and visual problem may
occur the first several days.
Pregnancy & Lactation
During pregnancy, this drug
should be used only if clearly needed. Since small amounts of this medication
are found in breast milk consult your doctor before medication.
Precautions & Warnings
Children are especially sensitive
to the 4-aminoquinoline compounds. Patients should be strongly warned to keep
these drugs out of the reach of children. Opthalmologic examination requires in
every 12 months.
Overdose Effects
Symptoms of overdose consist of
headache, drowsiness, visual disturbances, cardiovascular collapse, and
convulsions, followed by sudden and early respiratory and cardiac arrest.
Gastric lavage until the stomach is completely emptied.
Therapeutic Class
Anti-malarial drugs,
Disease-modifying antirheumatic drugs (DMARDs), Drugs used for Rheumatoid
Arthritis
Storage Conditions
Keep below 30°C temperature, away
from light & moisture. Keep out of the reach of children.
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