Medicine Overview of Cevion 1000mg Tablet
Indication
Treatment or prevention of, Vitamin C Deficiency, Scurvy,
Infection, Trauma, Burns, Cold exposure, Following Surgery, common cold, Fever,
scurvy, Stress, Cancer, Methaemoglobinaemia and Children receiving unfortified
formulas. Also indicated in, Hematuria, Dental Caries, Gum Diseases, Pyorrhea,
Acne, Infertility, Atherosclerosis, Fractures, Leg ulcers, Hay fever, Vascular
thrombosis prevention, Levodopa toxicity, Arsenic toxicity.
Administration
- May be taken with or without food. IV Preparation Dilute
with large volume of compatible fluid to minimize adverse reactions Compatible
w/ most common diluents (dextrose solns, NS, LR, Ringer's, ½NS,
dextrose-saline, dextrose-LR etc) IV Administration Avoid rapid infusion
Adult Dose
- Oral Scurvy Adult: Prevention: 25-75 mg daily. 4 tablets 2
to 3 times daily. Treatment: >250 mg daily, given in divided doses. May also
be given via IM/IV/SC admin. 250-500mg IV qDay/BID for at least 2 weeks.
Thalassaemia Adult: 100-200 mg daily, to be given with desferrioxamine. Common
cold: 1 gm or more daily in divided doses, i.e. 4 tablets daily. In wound
healing: 2-4 tablets 2 to 3 times daily In other conditions: 1-2 tablets daily
For the reduction of risk of stroke in the elderly: 1-2 tablets daily. 1 effervescent
tablet daily with a meal or as directed by physician. Dissolve one tablet in
half glass (100 ml) of water and drink instantly.
Child Dose
- Children: Child: 1 mth-4 yr: 125-250 mg daily; 4-12 yr:
250-500 mg daily; 12-18 yr: 500 mg-1 g daily. Doses to be given in 1-2 divided
doses. Thalassaemia Child: 100-200 mg daily, to be given with desferrioxamine.
Metabolic disorders Child: Neonate: 50-200 mg daily, adjust if needed; 1 mth-18
yr: 200-400 mg daily in 1-2 divided doses, up to 1 g daily may be needed.
Mode of Action
- Vitamin C: Necessary for collagen formation and tissue
repair; plays a role in oxidation/reduction reactions as well as other
metabolic pathways including synthesis of catecholamines, carnitine, and
steroids; also plays a role in conversion of folic acid to folinic acid.
Precaution
- Should be given with caution to patient with hyperoxaluria.
Side Effect
- Flushing, Flank pain, Faintness, headache, Diarrhea,
dyspepsia, nausea, vomiting, Hyperoxaluria (large doses)
Interaction
- Vit C: Deferroxamine, hormonal contraceptives, flufenazine,
warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram,
mexiletine, vitamin B12.
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