Indications
Cartilex Plus is indicated for the treatment of
osteoarthritis of knee, hip, spine, hand, and other locations as a dietary
supplement. It is also beneficial in rheumatoid arthritis, sport injuries,
migraine, different skin problems (e.g., psoriasis), vascular complications (e.
g., atherosclerosis), kidney stones, and inflammatory bowel disease (e.g.,
ulcerative colitis, leaky gut syndrome).
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Glucosamine is a natural amino-sugar, produced by the body
and found in certain foods. It is the most fundamental building block required
for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan
Sulfate, and Chondroitin Sulfate. GAGs binds with protein and form
proteoglycans, the essential building block of articular cartilage. When
cartilage in a joint deteriorates,Osteoarthritis develops. It also helps to
form ligaments, tendon, nails, and various other connective tissues.When we
take artificially synthesized Glucosamine Sulfate supplement, it increases
Glucosamine level in the body, thus facilitates production and repair of
cartilage. Glucosamine also activates chondrocytes in the cartilage which help
produce GAGs and proteoglycans.
Chondroitin Sulfate is a glycosaminoglycan (acid muco
polysaccharide) found in connective tissue, especially in the articular
cartilage of all mammals. Chondroitin Sulfate supplement acts similarly as
Glucosamine Sulfate, since it also provide substrate for proteoglycans.
Chondroitin also protects existing healthy cartilage from premature decline by
preventing the MMP (Matrix metalloproteinase) enzyme that breakdowns the
proteoglycans.
Combining Glucosamine with Chondroitin Sulfate shows
synergistic effect. Data supports that this combination has been shown to be
very much effective in severe cases of Osteoarthritis that treats both sign and
symptoms of Osteoarthritis & modifies disease progression. It prevents
Osteoarthritis in case of normal adults. In Osteoarthritic pain it is as
effective as NSAIDs with significantly better tolerability and clinical
compliance. It is also helpful during the repair phase of musculo-skeletal soft
tissue injuries such as tendon or ligament strains
Dosage & Administration
250/200 mg tablet: 1 to 2 tablets, three times daily. Dose
may be adjusted according to the response of the drug and body weight. Doses
can be tapered after 60 days as per requirement of the individual and for cost
convenience. Typical dosage recommendation, based on body weight is as follows-
Under 54 Kg: 1000 mg Glucosamine Sulfate & 800 mg
Chondroitin Sulfate per day
54 Kg to 91 Kg: 1500 mg Glucosamine Sulfate & 1200 mg
Chondroitin Sulfate per day
Over 91 Kg: 2000 mg Glucosamine Sulfate & 1600 mg
Chondroitin Sulfate per day.
750/600 mg tablet: 1 tablet two times daily or as directed
by the physician.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
There have been no reports of significant drug interactions
of Glucosamine and Chondroitin with Antibiotics/ Antidepressants/
Antihypertensives/ Nitrates/ Antiarrythmics/ Anxiolytics/ Hypoglycemic agents/
Antisecretives/ Antiasthmatics. Chondroitin may enhance the blood thinning
effects of anticoagulants like Warfarin, Heparin.
Contraindications
There are no known contraindications for Glucosamine and
Chondroitin. But proven hypersensitivity (e. g. allergic to shellfish or
sulfur) to Glucosamine and Chondroitin is a contraindication.
Side Effects
Safety studies with Glucosamine Sulfate & Chondroitin
Sulfate show no demonstrable side effects. Rarely occurring side effects (such
as, mild & reversible intestinal flatulence) are almost like placebo.
Pregnancy & Lactation
Women who are pregnant or who could become pregnant should
not supplement with Glucosamine Sulfate or Chondroitin Sulfate. Glucosamine and
Chondroitin has not been studied enough to determine their effects on a
developing fetus. No studies have evaluated the use of Glucosamine and
Chondroitin during pregnancy or lactation. It should be taken with caution and
medical advice during pregnancy and lactation.
Precautions & Warnings
Patients with Diabetes Mellitus are advised to monitor blood
glucose levels regularly when taking Glucosamine. No special studies were
formed in patients with renal or hepatic insufficiency. The toxicological and
pharmacokinetic profile of Glucosamine and Chondroitin does not indicate
limitations for these patients. However, administration to patients with severe
hepatic or renal insufficiency should be under appropriate medical supervision.
Children should not be supplemented with Glucosamine and Chondroitin.
Therapeutic Class
Stimulation of Cartilage formation
Storage Conditions
Store in a cool and dry place, protected from light.
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