Indications
Carticare TS is indicated for the
treatment of osteoarthritis of knee, hip, spine, hand, and other locations as a
dietary supplement. It is also beneficial in rheumatoid arthritis, sport
injuries, migraine, different skin problems (e.g., psoriasis), vascular
complications (e. g., atherosclerosis), kidney stones, and inflammatory bowel
disease (e.g., ulcerative colitis, leaky gut syndrome).
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Glucosamine is a natural
amino-sugar, produced by the body and found in certain foods. It is the most
fundamental building block required for biosynthesis of glycosaminoglycans
(GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. GAGs
binds with protein and form proteoglycans, the essential building block of
articular cartilage. When cartilage in a joint deteriorates,Osteoarthritis
develops. It also helps to form ligaments, tendon, nails, and various other
connective tissues.When we take artificially synthesized Glucosamine Sulfate
supplement, it increases Glucosamine level in the body, thus facilitates
production and repair of cartilage. Glucosamine also activates chondrocytes in
the cartilage which help produce GAGs and proteoglycans.
Chondroitin Sulfate is a
glycosaminoglycan (acid muco polysaccharide) found in connective tissue,
especially in the articular cartilage of all mammals. Chondroitin Sulfate
supplement acts similarly as Glucosamine Sulfate, since it also provide
substrate for proteoglycans. Chondroitin also protects existing healthy cartilage
from premature decline by preventing the MMP (Matrix metalloproteinase) enzyme
that breakdowns the proteoglycans.
Combining Glucosamine with
Chondroitin Sulfate shows synergistic effect. Data supports that this
combination has been shown to be very much effective in severe cases of
Osteoarthritis that treats both sign and symptoms of Osteoarthritis &
modifies disease progression. It prevents Osteoarthritis in case of normal
adults. In Osteoarthritic pain it is as effective as NSAIDs with significantly
better tolerability and clinical compliance. It is also helpful during the
repair phase of musculo-skeletal soft tissue injuries such as tendon or
ligament strains
Dosage & Administration
250/200 mg tablet: 1 to 2
tablets, three times daily. Dose may be adjusted according to the response of
the drug and body weight. Doses can be tapered after 60 days as per requirement
of the individual and for cost convenience. Typical dosage recommendation,
based on body weight is as follows-
Under 54 Kg: 1000 mg Glucosamine
Sulfate & 800 mg Chondroitin Sulfate per day
54 Kg to 91 Kg: 1500 mg
Glucosamine Sulfate & 1200 mg Chondroitin Sulfate per day
Over 91 Kg: 2000 mg Glucosamine
Sulfate & 1600 mg Chondroitin Sulfate per day.
750/600 mg tablet: 1 tablet two
times daily or as directed by the physician.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
There have been no reports of
significant drug interactions of Glucosamine and Chondroitin with Antibiotics/
Antidepressants/ Antihypertensives/ Nitrates/ Antiarrythmics/ Anxiolytics/
Hypoglycemic agents/ Antisecretives/ Antiasthmatics. Chondroitin may enhance
the blood thinning effects of anticoagulants like Warfarin, Heparin.
Contraindications
There are no known
contraindications for Glucosamine and Chondroitin. But proven hypersensitivity
(e. g. allergic to shellfish or sulfur) to Glucosamine and Chondroitin is a
contraindication.
Side Effects
Safety studies with Glucosamine
Sulfate & Chondroitin Sulfate show no demonstrable side effects. Rarely
occurring side effects (such as, mild & reversible intestinal flatulence)
are almost like placebo.
Pregnancy & Lactation
Women who are pregnant or who
could become pregnant should not supplement with Glucosamine Sulfate or
Chondroitin Sulfate. Glucosamine and Chondroitin has not been studied enough to
determine their effects on a developing fetus. No studies have evaluated the
use of Glucosamine and Chondroitin during pregnancy or lactation. It should be
taken with caution and medical advice during pregnancy and lactation.
Precautions & Warnings
Patients with Diabetes Mellitus
are advised to monitor blood glucose levels regularly when taking Glucosamine.
No special studies were formed in patients with renal or hepatic insufficiency.
The toxicological and pharmacokinetic profile of Glucosamine and Chondroitin
does not indicate limitations for these patients. However, administration to
patients with severe hepatic or renal insufficiency should be under appropriate
medical supervision. Children should not be supplemented with Glucosamine and
Chondroitin.
Therapeutic Class
Stimulation of Cartilage
formation
Storage Conditions
Store in a cool and dry place,
protected from light.
english
