Indications
Boxol is indicated in-
Productive cough
Acute and chronic inflammatory
disorders of upper and lower respiratory tracts associated with viscid mucus including
acute and chronic bronchitis
Inflammatory disease of
rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis)
associated with viscid mucus
Asthmatic bronchitis bronchial
asthma with thick expectoration
Bronchiectasis
Chronic pneumonia etc.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
Ambroxol is the active metabolite
of bromhexine and it has been proven that this metabolite possesses a greater
bronchosecretolytic effect than bromhexine. It improves sputum rheology by
hydrating mechanism leading to liquefaction of mucus in the lumen of
respiratory tract, thus facilitating expectoration of mucus and reducing
dyspnea. It stimulates production of phospholipids of surfactant by alveolar
cells, thus contributing to the lowering of superficial tension in the alveoli.
It also reduces bronchial hyperactivity. Ambroxol has anti inflammatory
properties owing to the inhibitory effect on the production of cellular
cytokines and arachidonic acid metabolites. In patients with COPD it
traditionally improves airway patency.
Dosage & Administration
Average daily dose (preferably
after meal):
Pediatric Drops:
0-6 months: 0.5 ml 2 times a day
6-12 months: 1 ml 2 times a day
1-2 years: 1.25 ml 2 times a day
Syrup:
2-5 years: 2.5 ml (1/2
teaspoonful) 2-3 times a day
5-10 years: 5 ml (1 teaspoonful)
2-3 times a day
10 years and adults: 10 ml (2
teaspoonful) 3 times a day.
Sustained release capsule: Adult
and children over 12 years old: 1 capsule once daily.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Boxol should not be taken
simultaneously with antitussives (e.g.Codeine) because phlegm, which has been
liquefied by Boxol might not be expectorated.
Contraindications
Contraindicated in known
hypersensitivity to Ambroxol or Bromhexine.
Side Effects
Gastrointestinal side effects
like epigastric pain, stomach overfill feeling may occur occasionally. Rarely
allergic responses such as eruption, urticaria or angioneurotic edema have been
reported.
Pregnancy & Lactation
Teratogenic and fetal toxicity
studies have shown no harmful effect of Ambroxol. However, it is advised not to
use it in pregnancy, especially during the1st trimester. Safety during
lactation has not been established yet.
Precautions & Warnings
Boxol should be given cautiously
to patients with gastric and duodenal ulceration or convulsive disorders.
Patients with hepatic and renal insufficiency should take it with caution.
Therapeutic Class
Cough expectorants &
mucolytics
Storage Conditions
Protect from direct light
exposure, Store in a dry place at a temperature not exceeding 30°C, Keep out of
the reach of children.
english
