Indications
This is indicated for symptomatic
relief of hyperacidity associated with the peptic ulcer, gastritis, peptic
oesophagitis, gastric hyperacidity, heartburn, sour stomach or hiatus hernia.
It is effective in the prevention of stress ulceration and GI bleeding. It acts
as an antiflatulent to alleviate the symptoms of gas including post operative
gas pain. This rapidly relieves acid pain, disperses gastric foam and
facilitates eructation of gas and air.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Composition
Each tablet contains-
Dried Aluminium Hydroxide Gel BP
(Al2O3, 47% minimum): 425.53 mg
Magnesium Hydroxide BP: 400 mg
Simethicone USP: 30 mg
Each 5 ml contains-
Aluminium Oxide (Equivalent
amount of Aluminium Hydroxide Gel USP): 200 mg
Magnesium Hydroxide (Equivalent
amount of Magnesium Hydroxide Paste USP): 400 mg
Simethicone USP: 30 mg
Pharmacology
This is the mixture of
non-systemic acid neutralizing substances and antiflatulent. This preparation
offers reliability as well as long action. Aluminium Hydroxide and Magnesium
Hydroxide induce the relief of ulcer by neutralizing gastric acid secreted from
parietal cells of the stomach. The clinical use of simethicone is based on its
antifoam properties. Simethicone spreads on the surface of aqueous liquids, forming
a film of low surface tension and causing collapse of foam bubbles. Simethicone
repeatedly allows mucous surrounded gas bubbles in the GI tract to coalesce and
be expelled
This is used in the treatment of
flatulence and meteorism for the elimination of gas, air or foam from the
gastro-intestinal tract prior to radiography and for the relief of abdominal
distension and dyspepsia.
Simethicone is physiologically
inert; it does not appeared to be absorbed from the GI tract to interfere with
gastric secretion or absorption of nutrients. Following oral administration,
the drug is excreted unchanged in the feces.
Dosage & Administration
Tablet: 1-2 tablets 1-3 hours
after meal and at bed time or as directed by the physician.
Suspension: 1-2 teaspoonful 1-3 hours
after meal and at bedtime or as directed by the physician.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
All antacids may increase or
decrease the rate and/or extent of absorption of concomitantly administered
oral drugs. Antacids decrease the bioavailability of theophyline, tetracycline,
quinolone antibiotics, isoniazide, ketoconazole, ethambutol, some
antimuscarinic drugs, benzodiazepines, phenothiazines, ranitidine,
indomethacine, nitrofurantoin, fluoride, phosphate, propanolol, atenolol,
digoxins, vitamins etc. Antacids increase the bioavailability of some drugs;
e.g. sulphonamides, levodopa, valproic acid, enteric coated aspirin etc.
Contraindications
This should not be administered
in patients with renal failure or hypophosphataemia or in those who are
severely debilitated. It is also contraindicated in alkalosis and
hypermagnesaemia, where abdominal distention may be due to partial or complete
intestinal obstruction.
Side Effects
Gastrointestinal side effects are
uncommon. Occasionally, if excessive amount is consumed, diarrhea, constipation
or regurgitation may occur.
Pregnancy & Lactation
It is advised to avoid antacid
preparations in the first trimester of pregnancy.
Precautions & Warnings
This should be used with caution
in patients with kidney disease.
Therapeutic Class
Antacids
Storage Conditions
Keep below 30°C temperature, away
from light & moisture. Keep out of the reach of children.
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