Indications
This is indicated for symptomatic relief of hyperacidity
associated with the peptic ulcer, gastritis, peptic oesophagitis, gastric
hyperacidity, heartburn, sour stomach or hiatus hernia. It is effective in the
prevention of stress ulceration and GI bleeding. It acts as an antiflatulent to
alleviate the symptoms of gas including post operative gas pain. This rapidly
relieves acid pain, disperses gastric foam and facilitates eructation of gas
and air.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Composition
Each tablet contains-
Dried Aluminium Hydroxide Gel BP (Al2O3, 47% minimum):
425.53 mg
Magnesium Hydroxide BP: 400 mg
Simethicone USP: 30 mg
Each 5 ml contains-
Aluminium Oxide (Equivalent amount of Aluminium Hydroxide
Gel USP): 200 mg
Magnesium Hydroxide (Equivalent amount of Magnesium
Hydroxide Paste USP): 400 mg
Simethicone USP: 30 mg
Pharmacology
This is the mixture of non-systemic acid neutralizing
substances and antiflatulent. This preparation offers reliability as well as
long action. Aluminium Hydroxide and Magnesium Hydroxide induce the relief of
ulcer by neutralizing gastric acid secreted from parietal cells of the stomach.
The clinical use of simethicone is based on its antifoam properties.
Simethicone spreads on the surface of aqueous liquids, forming a film of low
surface tension and causing collapse of foam bubbles. Simethicone repeatedly
allows mucous surrounded gas bubbles in the GI tract to coalesce and be
expelled.
This is used in the treatment of flatulence and meteorism
for the elimination of gas, air or foam from the gastro-intestinal tract prior
to radiography and for the relief of abdominal distension and dyspepsia.
Simethicone is physiologically inert; it does not appeared
to be absorbed from the GI tract to interfere with gastric secretion or
absorption of nutrients. Following oral administration, the drug is excreted
unchanged in the feces.
Dosage & Administration
Tablet: 1-2 tablets 1-3 hours after meal and at bed time or
as directed by the physician.
Suspension: 1-2 teaspoonful 1-3 hours after meal and at
bedtime or as directed by the physician.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
All antacids may increase or decrease the rate and/or extent
of absorption of concomitantly administered oral drugs. Antacids decrease the
bioavailability of theophyline, tetracycline, quinolone antibiotics,
isoniazide, ketoconazole, ethambutol, some antimuscarinic drugs,
benzodiazepines, phenothiazines, ranitidine, indomethacine, nitrofurantoin,
fluoride, phosphate, propanolol, atenolol, digoxins, vitamins etc. Antacids
increase the bioavailability of some drugs; e.g. sulphonamides, levodopa,
valproic acid, enteric coated aspirin etc.
Contraindications
This should not be administered in patients with renal
failure or hypophosphataemia or in those who are severely debilitated. It is
also contraindicated in alkalosis and hypermagnesaemia, where abdominal
distention may be due to partial or complete intestinal obstruction.
Side Effects
Gastrointestinal side effects are uncommon. Occasionally, if
excessive amount is consumed, diarrhea, constipation or regurgitation may
occur.
Pregnancy & Lactation
It is advised to avoid antacid preparations in the first
trimester of pregnancy.
Precautions & Warnings
This should be used with caution in patients with kidney
disease.
Therapeutic Class
Antacids
Storage Conditions
Keep below 30°C temperature, away from light & moisture.
Keep out of the reach of children
english
