Indications
This is indicated in-
Patients with essential hypertension
Patients with angina pectoris & hypertension as
co-existing diseases
ln post Ml patients
ln patients with refractory angina pectoris where nitrate
therapy has failed.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Pharmacology
This is a fixed-dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing afterload.
Atenolol is a cardioselective beta-blocker. The
cardio-selectivity is dose-related. Atenolol causes a reduction in blood
pressure by lowering cardiac output, decreasing the plasma renin activity and
sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial
oxygen demand by virtue of its negative inotropic and negative chronotropic
effects.
Dosage & Administration
The recommended dosage is Amlodipine and Atenolol 5/25 mg
tablet once daily. If necessary, the dosage may be increased to 5/25 mg two
tablets daily or as advised by the physicians. The dosage however should be
individualized.
* রেজিস্টার্ড
চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Disopyramide: Atenolol reduces the clearance of disopyramide by 20%. Additive negative inotropic effects on the heart may be produced.
Ampicillin: at doses of 1 gm and above may reduce Atenolol levels.
Oral antidiabetics and insulin: Beta-blockers may decrease
tissue sensitivity to insulin and inhibit insulin secretion e.g. in response to
oral antidiabetics. Atenolol has less potential for these actions.
Contraindications
Hypersensitivity to either component, sinus bradycardia,
second and higher degrees of heart block, cardiogenic shock, hypotension,
congestive heart failure, poor left ventricular function.
Side Effects
The combination of Amlodipine and Atenolol is well
tolerated. Overall side-effects include
fatigue, headache, edema, nausea, drowsiness, anxiety and
depression.
Pregnancy & Lactation
The combination should be used during pregnancy only if the
expected benefit outweighs the potential fetal risk. The combination should not
be used by nursing mothers. If its use is considered necessary, breast-feeding
should be stopped.
Precautions & Warnings
Bronchospasm: The combination should be used with caution in patients with airway obstruction.
Renal impairment: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min because of possible reduction in the excretion of unchanged Atenolol.
Hepatic impairment: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half-life of Amlodipine.
Drug withdrawal: Since coronary heart disease may exist
without being recognized, patients should be warned against stopping the drug
suddenly. Any discontinuation should be gradual and under observation.
Overdose Effects
Though not documented, hypotension and less frequently
congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs
may be removed by gastric lavage or administration of activated charcoal.
Symptomatic treatment is suggested.
Therapeutic Class
Combined antihypertensive preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture.
Keep out of the reach of children.
No review given yet!
You need to Sign in to view this feature
This address will be removed from this list